There are a number of different tests used to diagnose AT. Using the cell type white blood cells, specific tests can be performed to determine whether the patient has the abnormal ATM protein. Ninety percent of patients have no detectable ATM protein in their cells. Ten percent of those with AT have trace amounts of the protein in their cells. In the remaining 1 percent, the person has the normal level of the ATM protein. In these people, the AT protein cannot function properly.
The AT genetic test will reveal if your child has the altered ATM gene. This test can give you important information for your family. For instance, if your daughter is diagnosed with the condition, the genetic counselor will be able to tell her mother had the altered gene and the father did not. A carrier of the ATM gene has a slightly higher risk for coronary artery disease, but will not have AT. However, if the ATM gene copy in her mother was normal, there would be no problem with the child having the AT gene.
While there are many types of AT devices available, the most important is that they are used in conjunction with a multidisciplinary team of professionals. The team may include family doctors, regular and special education teachers, speech-language pathologists, and rehabilitation engineers. Manufacturers and service organizations also offer valuable information on the best options for your child. Luckily, many government programs and school systems provide funding for the general special education materials. Additionally, the government is willing to pay for the AT that your doctor prescribes.
The ATM gene regulates cell division when DNA is damaged. After DNA damage, the ATM protein triggers the accumulation of the p53 protein. This prevents cells from dividing. However, if the ATM gene is altered, the p53 protein does not accumulate properly, which leads to the continued replication of the cells. This leads to increased cancer risk. In addition to the risks of developing leukemia and lymphoma, these cells will also be prone to developmental problems and neurological disorders.
People with this disease are born with an altered ATM gene. The ATM gene is located on the long arm of the chromosome 11. This enzyme regulates the cell division process after DNA damage. The symptoms of ataxia telangiectasia include tremors and diminished coordination. The affected individual also has an impaired immune system, increasing the risk of developing respiratory infections. In addition, individuals with AT have a higher risk of developing certain cancers.